Fri Jun 24 2022

92 articles - From Friday Jun 17 2022 to Friday Jun 24 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Lancet

Opioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials.

Given these limitations, there is a great need to advance the quality and scope of research in this field. Funding The Canadian Institutes of Health Research.

Pubmed   Journal   ReadQx 


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Race, Genotype, and Azathioprine Discontinuation : A Cohort Study.

Patients with the CC genotype had higher risk for azathioprine discontinuation attributed to hematopoietic toxicity and lower thiopurine doses. Genotype was associated with those risks, even after adjustment for race. Primary funding source National Institutes of Health.

Pubmed   Journal   ReadQx 

Reforming Physician Payments to Achieve Greater Equity and Value in Health Care: A Position Paper of the American College of Physicians.

Evidence-based services and programs in Medicare Part B that are shown to preserve the Medicare trust fund through savings in Part A should be able to be scored as offsets for the cost of those new programs. The approach of building a health care system that is smarter about how dollars are spent to make people healthier must shift to one with a clear intention of decreasing health inequities and addressing social drivers of health.

Pubmed   Journal   ReadQx 

Lancet

Life expectancy by county, race, and ethnicity in the USA, 2000-19: a systematic analysis of health disparities.

Local-level data are crucial to address the root causes of poor health and early death among disadvantaged groups in the USA, eliminate health disparities, and increase longevity for all. Funding National Institute on Minority Health and Health Disparities; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institute on Aging; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Office of Disease Prevention; and Office of Behavioral and Social Science Research, US National Institutes of Health.

Pubmed   Journal   ReadQx 

Lisocabtagene maraleucel versus standard of care with salvage chemotherapy followed by autologous stem cell transplantation as second-line treatment in patients with relapsed or refractory large B-cell lymphoma (TRANSFORM): results from an interim analysis of an open-label, randomised, phase 3 trial.

Interpretation These results support liso-cel as a new second-line treatment recommendation in patients with early relapsed or refractory LBCL. Funding Celgene, a Bristol-Myers Squibb Company.

Pubmed   Journal   ReadQx 

Once daily oral relugolix combination therapy versus placebo in patients with endometriosis-associated pain: two replicate phase 3, randomised, double-blind, studies (SPIRIT 1 and 2).

This oral therapy has the potential to address the unmet clinical need for long-term medical treatment for endometriosis, reducing the need for opioid use or repeated surgical treatment. Funding Myovant Sciences.

Pubmed   Journal   ReadQx 

N Engl J Med

Chapare Hemorrhagic Fever and Virus Detection in Rodents in Bolivia in 2019.

The etiologic agent was identified as . (Funded by the Bolivian Ministry of Health and others.).

Pubmed   Journal   ReadQx 

Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections.

No discernable differences in protection against symptomatic BA.1 and BA.2 infection were seen with previous infection, vaccination, and hybrid immunity. Vaccination enhanced protection among persons who had had a previous infection. Hybrid immunity resulting from previous infection and recent booster vaccination conferred the strongest protection. (Funded by Weill Cornell Medicine-Qatar and others.).

Pubmed   Journal   ReadQx 

Genetically Modified Porcine-to-Human Cardiac Xenotransplantation.

Studies are under way to identify the mechanisms responsible for these changes. (Funded by the University of Maryland Medical Center and School of Medicine.).

Pubmed   Journal   ReadQx 

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit.

In adults with sepsis receiving vasopressor therapy in the ICU, those who received intravenous vitamin C had a higher risk of death or persistent organ dysfunction at 28 days than those who received placebo. (Funded by the Lotte and John Hecht Memorial Foundation; LOVIT ClinicalTrials.gov number, NCT03680274.).

Pubmed   Journal   ReadQx 

Maternal Vaccination and Risk of Hospitalization for Covid-19 among Infants.

Maternal vaccination with two doses of mRNA vaccine was associated with a reduced risk of hospitalization for Covid-19, including for critical illness, among infants younger than 6 months of age. (Funded by the Centers for Disease Control and Prevention.).

Pubmed   Journal   ReadQx 

Restriction of Intravenous Fluid in ICU Patients with Septic Shock.

Among adult patients with septic shock in the ICU, intravenous fluid restriction did not result in fewer deaths at 90 days than standard intravenous fluid therapy. (Funded by the Novo Nordisk Foundation and others; CLASSIC ClinicalTrials.gov number, NCT03668236.).

Pubmed   Journal   ReadQx 

Sequential Stem Cell-Kidney Transplantation in Schimke Immuno-osseous Dysplasia.

Full donor hematopoietic chimerism and functional ex vivo T-cell tolerance was achieved, and the patients continued to have normal renal function without immunosuppression at 22 to 34 months after kidney transplantation. (Funded by the Kruzn for a Kure Foundation.).

Pubmed   Journal   ReadQx 

Treatment of Anal High-Grade Squamous Intraepithelial Lesions to Prevent Anal Cancer.

Among participants with biopsy-proven anal HSIL, the risk of anal cancer was significantly lower with treatment for anal HSIL than with active monitoring. (Funded by the National Cancer Institute; ClinicalTrials.gov number, NCT02135419.).

Pubmed   Journal   ReadQx 

Vaccine Efficacy in Adults in a Respiratory Syncytial Virus Challenge Study.

RSVpreF vaccine was effective against symptomatic RSV infection and viral shedding. No evident safety concerns were identified. These findings provide support for further evaluation of RSVpreF vaccine in a phase 3 efficacy study. (Funded by Pfizer; EudraCT number, 2020-003887-21; ClinicalTrials.gov number, NCT04785612.).

Pubmed   Journal   ReadQx 


Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Monkeypox: Avoiding the Mistakes of Past Infectious Disease Epidemics.

Pubmed   Journal   ReadQx 

Lancet

Attitudes towards menopause: time for change.

Pubmed   Journal   ReadQx 

Offline: WHO's hits and misses for mental health.

Pubmed   Journal   ReadQx 

N Engl J Med

A Challenge to Respiratory Syncytial Virus Illness in Adults.

Pubmed   Journal   ReadQx 

Audio Interview: Vaccinating Young Children against Covid-19.

Pubmed   Journal   ReadQx 

Audio Interview: Viral Evolution and the Future of Monoclonal Antibodies.

Pubmed   Journal   ReadQx 

Climate Change, Fossil-Fuel Pollution, and Children's Health.

Pubmed   Journal   ReadQx 

Covid-19 Vaccination during Pregnancy - Two for the Price of One.

Pubmed   Journal   ReadQx 

Fossil-Fuel Pollution and Climate Change - A New NEJM Group Series.

Pubmed   Journal   ReadQx 

Genetic Modification in Pig-to-Human Transplantation.

Pubmed   Journal   ReadQx 

Intravenous Fluids in Septic Shock - More or Less?

Pubmed   Journal   ReadQx 

Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.

Pubmed   Journal   ReadQx 

The Future of Transplantation.

Pubmed   Journal   ReadQx 

Transplantation Tolerance through Hematopoietic Chimerism.

Pubmed   Journal   ReadQx 


Letters&Replies

Letters to the editors and authors’ replies

Lancet

Gender equality and climate action: lessons from evidence on SRHR.

Pubmed   Journal   ReadQx 

Monkeypox in the UK: arguments for a broader case definition.

Pubmed   Journal   ReadQx 

Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2.

Pubmed   Journal   ReadQx 

Supporting cancer survivors in LMICs.

Pubmed   Journal   ReadQx 

Where are the children and adolescents?

Pubmed   Journal   ReadQx 

N Engl J Med

Association between Covid-19 Vaccination and Influenza Vaccination Rates.

Pubmed   Journal   ReadQx 

Darolutamide in Metastatic Prostate Cancer.

Pubmed   Journal   ReadQx 

Darolutamide in Metastatic Prostate Cancer.

Pubmed   Journal   ReadQx 

Darolutamide in Metastatic Prostate Cancer. Reply.

Pubmed   Journal   ReadQx 

Endovascular Therapy for Large Acute Strokes.

Pubmed   Journal   ReadQx 

Endovascular Therapy for Large Acute Strokes. Reply.

Pubmed   Journal   ReadQx 

Evaluation of Acute Adverse Events after Covid-19 Vaccination during Pregnancy.

Pubmed   Journal   ReadQx 

Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5.

Pubmed   Journal   ReadQx 

Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants.

Pubmed   Journal   ReadQx 

Protection against SARS-CoV-2 after Vaccination and Previous Infection.

Pubmed   Journal   ReadQx 

Protection against SARS-CoV-2 after Vaccination and Previous Infection. Reply.

Pubmed   Journal   ReadQx 

Shorter Treatment for Tuberculosis in Children.

Pubmed   Journal   ReadQx 

Shorter Treatment for Tuberculosis in Children.

Pubmed   Journal   ReadQx 

Shorter Treatment for Tuberculosis in Children. Reply.

Pubmed   Journal   ReadQx 

Ten Years of Choosing Wisely to Reduce Low-Value Care.

Pubmed   Journal   ReadQx 

Ten Years of Choosing Wisely to Reduce Low-Value Care.

Pubmed   Journal   ReadQx 

Ten Years of Choosing Wisely to Reduce Low-Value Care.

Pubmed   Journal   ReadQx 

Ten Years of Choosing Wisely to Reduce Low-Value Care. Reply.

Pubmed   Journal   ReadQx 

Trastuzumab Deruxtecan for Breast Cancer.

Pubmed   Journal   ReadQx 

Trastuzumab Deruxtecan for Breast Cancer. Reply.

Pubmed   Journal   ReadQx 

Troponin I after Cardiac Surgery and 30-Day Mortality.

Pubmed   Journal   ReadQx 

Troponin I after Cardiac Surgery and 30-Day Mortality.

Pubmed   Journal   ReadQx 

Troponin I after Cardiac Surgery and 30-Day Mortality. Reply.

Pubmed   Journal   ReadQx 


Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals for Educators - June 2022.

Pubmed   Journal   ReadQx 

Beyond Race: A Wake-up Call for Drug Therapy Informed by Genotyping.

Pubmed   Journal   ReadQx 

Potential Medicare Part D Savings on Generic Drugs From the Mark Cuban Cost Plus Drug Company.

Pubmed   Journal   ReadQx 

The Emperor Has No Ganey.

Pubmed   Journal   ReadQx 

The Emperor Has No Ganey.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals Consult Guys - Frailty: Its Role as a Risk Factor in Surgery.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals for Hospitalists Inpatient Notes - Venous Thromboembolism Prophylaxis in COVID-19: Making Sense of the Evidence.

Pubmed   Journal   ReadQx 

Web Exclusive. Annals On Call - Time for a Bisphosphonate Holiday?

Pubmed   Journal   ReadQx 

Lancet

Bilateral renal lymphangiomatosis causes swelling and lower back pain.

Pubmed   Journal   ReadQx 

Data aggregation hides Pacific Islander health disparities.

Pubmed   Journal   ReadQx 

Fears for Iranian-Swedish doctor held on espionage charges.

Pubmed   Journal   ReadQx 

Investigating monkeypox.

Pubmed   Journal   ReadQx 

Memorialising COVID-19.

Pubmed   Journal   ReadQx 

Opioid-free analgesia after surgery.

Pubmed   Journal   ReadQx 

Partnering to deliver sustainable children's surgical care in Kakuma refugee camp.

Pubmed   Journal   ReadQx 

Poland to introduce controversial pregnancy register.

Pubmed   Journal   ReadQx 

Relugolix combination therapy for endometriosis pain.

Pubmed   Journal   ReadQx 

Second-line CAR T cells for lymphomas.

Pubmed   Journal   ReadQx 

UK scientists warn over threat to Horizon funding.

Pubmed   Journal   ReadQx 

Ursula Bellugi.

Pubmed   Journal   ReadQx 

N Engl J Med

A Preview of the Dangerous Future of Abortion Bans - Texas Senate Bill 8.

Pubmed   Journal   ReadQx 

Building a National Public Health System in the United States.

Pubmed   Journal   ReadQx 

Bumps in the Road.

Pubmed   Journal   ReadQx 

Case 18-2022: A 29-Year-Old Woman with Recurrent Fractures.

Pubmed   Journal   ReadQx 

Case 19-2022: A 29-Year-Old Woman with Jaundice and Chronic Diarrhea.

Pubmed   Journal   ReadQx 

Case 24-2022: A 31-Year-Old Man with Perianal and Penile Ulcers, Rectal Pain, and Rash.

Pubmed   Journal   ReadQx 

Clinical Examination of the Hip.

Pubmed   Journal   ReadQx 

Enrollee Premiums in Medicaid - Insights from Michigan.

Pubmed   Journal   ReadQx 

IgG4-Related Ophthalmic Disease.

Pubmed   Journal   ReadQx 

Monkeypox Genital Lesions.

Pubmed   Journal   ReadQx 

Reducing Administrative Harm in Medicine - Clinicians and Administrators Together.

Pubmed   Journal   ReadQx 

Second Branchial Cleft Cyst.

Pubmed   Journal   ReadQx 

The Critical Shortage of Iodinated Contrast Material - Will Value Prevail?

Pubmed   Journal   ReadQx 

The Emergence of the Racial Disparity in U.S. Breast-Cancer Mortality.

Pubmed   Journal   ReadQx 

Unexpected Closure.

Pubmed   Journal   ReadQx